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Drug ReportsEstrogens, esterified
Estrogens esterified
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, esterified) is an unknown pharmaceutical. Estrogens, esterified was first approved as Amnestrogen on 1982-01-01.
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlordiazepoxide
+
Estrogens
+
esterified
Tradename
Company
Number
Date
Products
MENRIUM 5-2RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 5-4RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 10-4RocheN-014740 DISCN1982-01-01
1 products
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FDA
EMA
Brand Name
Status
Last Update
covaryxunapproved drug other2020-01-25
covaryx covaryxunapproved drug other2013-02-26
eemtunapproved drug other2020-01-22
eemt eemtunapproved drug other2013-03-01
esterified estrogens and methyltestosteroneunapproved drug other2025-02-10
esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strengthunapproved drug other2025-03-10
esterified estrogens and methytestesteroneunapproved drug other2022-11-25
estratest f.s.unapproved drug other2024-09-06
estratest f.s. estratest h.s.unapproved drug other2024-06-15
estratest fs estratest hsunapproved drug other2025-03-10
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
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FDA Information
Bazedoxifene Acetate / Estrogens, Conjugated, Duavee, Wyeth Pharms
76830512027-03-10DS, DPU-594, U-904
76830512027-03-10DS, DPU-594, U-904
76830512027-03-10DS, DPU-594, U-904
76830512027-03-10DS, DPU-594, U-904
ATC Codes
G: Genito urinary system and sex hormones
G03: Sex hormones and modulators of the genital system
G03A: Hormonal contraceptives for systemic use
G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
G03AA14: Nomegestrol and estradiol
G03AA17: Medroxyprogesterone and estradiol
G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
G03AB08: Dienogest and estradiol
G03C: Estrogens, sex hormones and modulators of the genital system
G03CA: Natural and semisynthetic estrogens, plain
G03CA03: Estradiol
G03CA53: Estradiol, combinations
H: Systemic hormonal preparations, excl. sex hormones and insulins
H01: Pituitary and hypothalamic hormones and analogues
H01C: Hypothalamic hormones
H01CC: Anti-gonadotropin-releasing hormones
H01CC53: Elagolix, estradiol and norethisterone
H01CC54: Relugolix, estradiol and norethisterone
HCPCS
No data
Clinical
Clinical Trials
158 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MenopauseD008593EFO_0003922N956847227
PostmenopauseD0176988532321
AtrophyD001284251210
Atrophic vaginitisD059268EFO_100127123319
Hot flashesD01958414229
VaginitisD014627EFO_0005757N7631329
Pelvic organ prolapseD056887EFO_00047101427
ProlapseD0113911427
Overactive urinary bladderD053201EFO_1000781N32.81426
HyperplasiaD006965EFO_00005362215
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Indications Phases 3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypersensitivityD006967EFO_0003785T78.4022
Lymphatic metastasisD008207EFO_100136411
Risk reduction behaviorD04024211
Cognitive dysfunctionD060825G31.8411
Multiple sclerosisD009103EFO_0003885G3511
SclerosisD01259811
Carcinoma in situD002278D09.911
Breast carcinoma in situD000071960D0511
Ductal carcinoma breastD01827011
Intraductal carcinoma noninfiltratingD002285D05.111
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Indications Phases 1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoarthritisD010003EFO_0002506M15-M1911
Postoperative painD010149G89.1811
Gender dysphoriaD000068116F6411
Breast densityD00007106011
DementiaD003704EFO_0003862F0311
Male breast neoplasmsD01856711
Heart failureD006333EFO_0003144I5011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEstrogens esterified
INN_
Description
17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol.
Classification
Unknown
Drug classestrogens; steroids (androgens, anabolics)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID141290-02-0
RxCUI
ChEMBL IDCHEMBL1201468
ChEBI ID
PubChem CID
DrugBankDB09381
UNII ID3ASP8Q3768 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Premarin Pfizer
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,034 documents
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Safety
Black-box Warning
Black-box warning for: Covaryx, Covaryx covaryx, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength, Esterified estrogens and methytestesterone, Estratest f.s., Estratest f.s. estratest h.s., Estratest fs estratest hs, Menest
Adverse Events
Top Adverse Reactions
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61,069 adverse events reported
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